Isaiah, Jeremiah, and especially Ezekiel and Hosea use this same metaphorical form to illustrate Israel's faithless relationship with God, connecting directly to the same usage in Revelation 17 and 18. Why is this important? Virtually the entire Bible is devoted to God's purpose for and relationship to Israel and the church. They are the focus of God's intention to reproduce Himself, beginning with His promises and then His covenant with Abraham. God went so far as to enter into a symbolic marriage with Israel, the physical descendants of Abraham, revealing the intimacy He considered their relationship to have.
He did this with no other nation. Even when the time came to summon Gentiles into His purpose, the great bulk of those called into the church have been Israelites dwelling among fellow Israelites in Israelitish lands. A person even becomes a spiritual Jew when converted! God's pattern of focusing on Israel continues throughout the Bible to the end-time prophecies. We live in the end time, and God's concern in Revelation, the ultimate end-time book, does not turn from this pattern. God's purpose for the nation of Israel is not yet complete, as Romans 9-11 makes clear.
Thus Israel, the physical descendants of Abraham, and the church, the Israel of God, Abraham's spiritual descendants, are still His major focus. Other parts of the Bible reveal that Israel has fully earned the title of "the Great Harlot Babylon" even as she has earned the titles of "Sodom" and "Egypt."
The Great Harlot of Revelation 17 and 18 is not a Gentile church or a Gentile nation because neither of these has ever qualified for that title by corrupting a covenant relationship with God as Israel has. Of this, God says in Amos 3:2, "You only have I known of all the families of the earth; therefore I will punish you for all your iniquities." Having done only what comes naturally without the revelation of God, the Gentile world will have its opportunity to have a covenant relationship with Him following Christ's return.
In defiance of God, Israel has rebelled against her responsibilities and played the harlot with the world. She has embraced its ways to such an extent that she has outdone the Gentiles in their manner of life, becoming appropriately named "Babylon the Great." In Revelation 17 and 18, God is describing the influence and character of end-time Israel. He depicts all of Israel in close relationship with the Beast, influencing it, but with the two Joseph tribes, America (Manasseh) and Britain (Ephraim), as the Woman's strongest components - and perhaps America is the one primarily described, as it is the most influential at the end.