This brings together two factors: Sin and God's sovereignty. Because the earth requires maintenance and therefore dominion, and because God gave dominion to mankind, the rest of creation shares in the way mankind lives. Thus, when mankind sins, nature will be affected and react to some extent. In verse 25, God personifies the land as a living creature that violently rejects what it dislikes.
The context shows the iniquity to be spiritual and that God is personally involved in what happens when mankind sins. This confronts us again with whether God actively governs this world. Has He, as it appears in Leviticus 18, set limits on the evil mankind can do?
Suppose man is totally free to choose as he pleases, and it is impossible to compel or coerce him without destroying this freedom. If so, it follows that man is sovereign, doing as he pleases—the designer and architect of his destiny. Given man's history, we can have no assurance whatsoever that morality will not gradually disappear, and that anarchy, barbarism, and eventual genocide will not arise in its absence. It is absolutely imperative that God be sovereign to govern the antics of the very creatures He created! His reaction in the Flood and at the Tower of Babel is strong evidence of this.